This session is co-chaired by EDCTP and the European Clinical Research Infrastructure Network (ECRIN) and brings together key global health actors to collectively discuss the next steps towards the comprehensive mobilisation of all the stakeholders necessary for building sustainable clinical research infrastructure, skills development, and strengthening of institutions for the development and uptake of safe and effective R&I products in Africa. A set of recommendations on clinical trial infrastructure and capacity building in Africa arising from a session hosted by ECRIN and EDCTP on 17 June 2021 at the Africa-Europe Science and Innovation Summit will also be further discussed. Several panellists will take part in a policy roundtable on EU-AU research and innovation cooperation for the development of sustainable clinical research infrastructures and a skilled workforce in Africa.